Not approved, not coveredSelank has no FDA approval,[1] and the FDA says it "lacks important information regarding any safety issues raised by selank acetate administered to humans."[2] The calculator does arithmetic only.
What is the selank peptide?
Selank is the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro, listed by the FDA as "Selank acetate (TP-7)".[14][2]
- Sequence
- TKPRPGP[14]
- Formula and weight
- C33H57N11O9, 751.9 g/mol
- Other name
- TP-7
Regulatory status in November 2026
Selank left the FDA's Category 2 list for an unusual reason, and it has not been reviewed or covered since.
| Date | What happened |
|---|---|
| Sept 29, 2023 | Placed in 503A Category 2[3] |
| Sept 27, 2024 | Removed "because FDA received additional information from the nominator indicating that they intended to nominate a different bulk drug substance" |
| Apr 22, 2026 | Listed in FDA's "nominated but withdrawn" safety table[2] |
| Oct 30, 2026[4] | Not included in the HHS enforcement-discretion policy |
- No advisory committee review. Selank was not on any FDA Pharmacy Compounding Advisory Committee agenda from 2024 to 2026, and the FDA has published no briefing document on it.
- Enforcement. FDA warning letters in 2020 and 2021 named selank among substances not eligible for compounding.[5][6]
- Sport: not named on the WADA 2026 list; from 2027 the list names "peptides" in general under S0.[12][13]
Selank dosage in published studies
The published human studies are Russian anxiety trials of 60 to 70 patients, and their indexed abstracts do not state the dose or route.
| Study | People | Comparison | Reported (abstract) |
|---|---|---|---|
| Zozulia 2008[7] | 62 patients with generalized anxiety disorder or neurasthenia | Medazepam | "Anxiolytic effects of both drugs were similar"; no adverse event data in abstract |
| Medvedev 2014[8] | 60 patients with phobic-anxiety and somatoform disorders | Phenazepam | Anxiolytic effect reported to last a week after the last dose |
| Medvedev 2015[9] | 70 patients | Phenazepam alone vs selank added | Fewer phenazepam side effects with the combination |
| Uchakina 2008[10] | Patients with anxiety disorders; number not in abstract | None | Changes in immune signaling molecules |
| Panikratova 2020[11] | 52 healthy adults | Placebo (and semax) | Changes in amygdala connectivity on brain scans |
No selank study is registered on ClinicalTrials.gov, and we did not find an English-language placebo-controlled trial. Without doses in the published record, there is no selank dosage to report.
Selank vs semax
The two are often mentioned together because both are seven amino acids long and end in Pro-Gly-Pro, but their regulatory paths differ.
| Selank | Semax | |
|---|---|---|
| Sequence | TKPRPGP | MEHFPGP[15] |
| FDA advisory committee | Never reviewed | Reviewed July 2026; FDA proposed against |
| HHS 2026 policy | Not covered | Covered, intranasal only |
| Human studies | Small anxiety trials | Small stroke and other trials, intranasal |
Details are on the semax peptide page.
Selank peptide dosage chart (concentration only)
This chart shows only what one syringe unit holds. At 751.9 g/mol, 100 mcg is 133 nmol.
| Vial + liquid | mg/mL | mcg per unit | nmol per unit | Units per 100 mcg |
|---|---|---|---|---|
| 1 mg + 1 mL | 1 | 10 | 13.3 | 10 |
| 1 mg + 2 mL | 0.5 | 5 | 6.65 | 20 |
| 5 mg + 1 mL | 5 | 50 | 66.5 | 2 |
| 5 mg + 2 mL | 2.5 | 25 | 33.25 | 4 |
| 10 mg + 1 mL | 10 | 100 | 133 | 1 |
| 10 mg + 2 mL | 5 | 50 | 66.5 | 2 |
Example arithmetic: a 1 mg vial with 1 mL holds 10 mcg per unit, so 100 mcg is 10 units.
Other peptide pages
The peptides most often looked up alongside this one. Each page gives that peptide's FDA status, compounding status and published human evidence, with sources; the status table has all 23 in one place.
- PT-141 (bremelanotide)FDA-approved Vyleesi: a prefilled 1.75 mg autoinjector. No mixing needed.
- SemaxNot approved ACTH-based heptapeptide. Intranasal studies only.
- MT2 (melanotan II)Not approved Melanotan II. Never approved; FDA cites melanoma reports.
- DSIP (emideltide)Not approved Delta sleep-inducing peptide. Small IV studies, 1981–1998.
- BPC-157Not approved 15-amino-acid peptide. Human data: a few tiny, uncontrolled studies.
- TB-500Not approved A 7-amino-acid fragment of thymosin beta-4. No human trials of TB-500 itself.
Frequently asked questions
What is the selank dosage?
Is selank legal in the US?
It is not FDA-approved, it is not on the 503A bulks list, and it is not covered by the 2026 HHS compounding policy.[4][3] See are peptides legal? This is not legal advice.
Is selank a nasal spray?
No selank nasal spray is approved in the U.S. The indexed abstracts of the published trials do not state the route, and we could not confirm a foreign label.[7] Semax, by contrast, was studied almost entirely as nose drops; see the semax page.
Why was selank removed from Category 2?
Because the nominator told the FDA it had meant to nominate a different substance, not because of new safety data.[3]
Is selank FDA-approved?
No. There is no FDA application for selank.[1]
Sources
- openFDA Drugs@FDA searches for AOD-9604, KPV, epitalon, semax, selank, cagrilintide, melanotan and NAD (no application found)
- Certain bulk drug substances for use in compounding that may present significant safety risks
- Bulk drug substances nominated for use in compounding under section 503A (category lists)
- Enforcement discretion policy regarding 503A compounding using certain peptide bulk drug substances (91 FR 68526)
- Warning letter: Tailor Made Compounding LLC
- Warning letter: Advanced Nutriceuticals LLC dba The Guyer Institute of Molecular Medicine
- Zozulia AA et al. Selank vs medazepam in anxiety disorders (Zh Nevrol Psikhiatr 2008;108:38–48)
- Medvedev VE et al. Selank vs phenazepam in phobic-anxiety disorders (Zh Nevrol Psikhiatr 2014;114:17–22)
- Medvedev VE et al. Selank added to phenazepam (Zh Nevrol Psikhiatr 2015;115:33–40)
- Uchakina ON et al. Selank and cytokines in anxiety disorders (Zh Nevrol Psikhiatr 2008;108:71–5)
- Panikratova YR et al. Semax, selank and amygdala connectivity (Dokl Biol Sci 2020;490:9–11)
- World Anti-Doping Code: Prohibited List 2026
- Athlete advisory: what's new on the 2027 WADA Prohibited List
- PubChem CID 11765600: selank
- PubChem CID 9811102: semax